NCAA Tournament East Region Breakdown: Top matchups, upsets, predictions

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The East Region: A Region of Stars

The East Region of the 2025 NCAA Men’s Basketball Tournament is aptly dubbed the "Region of Stars," showcasing some of the most elite talent in college basketball. Headlining this star-studded lineup is Cooper Flagg, the nation’s top player and projected No. 1 NBA Draft pick, who leads Duke University. Alongside him, Mark Sears of Alabama, John Tonje of Wisconsin, and Caleb Love of Arizona highlight a region brimming with individual brilliance and team potential. These players bring not only incredible skill but also storied resumes, with Flagg’s generational talent and Sears’ Final Four experience setting the tone for what promises to be a thrilling tournament. The East Region is a melting pot of proven champions, rising stars, and teams on the cusp of making history, making it one of the most compelling regions to watch. With Duke, Alabama, and Arizona leading the charge, this region is primed for intense competition and unforgettable moments.

Can Duke Make Its First Final Four with Cooper Flagg?

Duke University enters the East Region as one of the most dominant teams, thanks in large part to the sensational play of freshman phenom Cooper Flagg. Flagg, who averaged 19 points, 8 rebounds, and 4 assists per game during the regular season, is the crown jewel of this Duke squad. Despite nursing an ankle injury, his return to the court is eagerly anticipated, and his impact on both ends of the floor could be the key to the Blue Devils’ success. Coach Jon Scheyer’s team is built for a deep tournament run, featuring Tyrese Proctor’s leadership, Kon Knueppel’s sharpshooting, and Khaman Maluach’s rim protection. Duke’s mistake-free basketball, with only nine turnovers per game, is a testament to their discipline and composure. If Flagg is healthy, the Blue Devils appear nearly unstoppable, and their path to the Elite Eight seems all but certain. The question now is, can they finally reach Scheyer’s first Final Four? With their favorable draw and loaded roster, the answer seems likely.

Evaluating the Top Seeds and Their Draws

Among the top four seeds in the East Region, Duke undeniably has the most favorable draw. The Blue Devils are poised to cruise to the Sweet 16, with a second-round matchup against either Mississippi State or Baylor. Both potential opponents have struggled with consistency, making Duke’s path to the second weekend relatively smooth. While other top seeds like Alabama and Arizona cannot be overlooked, Duke’s balance and depth make them the team to beat. Alabama, led by Mark Sears, is a legitimate contender, having reached the Final Four last year. However, the Crimson Tide’s inconsistent play this season leaves some questions unanswered. Arizona, meanwhile, is dangerous with Caleb Love’s explosive scoring ability, but their inconsistency and defensive vulnerabilities could hinder their progress. Oregon and BYU also have the potential to make noise, but they face tough matchups that will test their mettle. Ultimately, Duke’s combination of talent, coaching, and draw makes them the clear favorite in the East.

Intriguing Matchups and Potential Upsets

The East Region is filled with captivating matchups that could shake up the bracket. One of the most anticipated games in the first round is the 6 vs. 11 showdown between BYU and VCU. BYU, ranked 11th in KenPom offensive efficiency, boasts a high-powered offense led by Richie Saunders and Egor Demin, while VCU, the A-10 champion, brings a top-25 defense and a balanced attack led by Max Shulga. This matchup has all the makings of a classic, with both teams capable of making a deep run. Another intriguing game is Liberty vs. Oregon, where Dana Altman’s coaching prowess could help the Ducks overcome their guard play limitations. However, the most surprising upset pick in the region is Akron over Arizona. Akron, under John Groce, has a well-rounded offense and a top-20 tempo, making them a formidable opponent for the inconsistent Wildcats. With Arizona’s struggles on defense, the Zips could pull off the upset behind the Johnson brothers, Nate and Tavari. This region is full of potential upsets, keeping fans on the edge of their seats.

Must-See Players in the East Region

The East Region boasts an array of talent that makes it a must-watch for basketball fans. At the top of the list is Cooper Flagg, the consensus No. 1 draft pick who has already shown glimpses of his NBA-ready skills. His ability to dominate on both ends of the floor is a rare commodity, and his performance in the tournament will be one of the biggest storylines. Mark Sears of Alabama is another player to watch, as his All-American credentials and ability to take over games could lead the Crimson Tide back to the Final Four. Caleb Love, the explosive guard from Arizona, is a wildcard who can single-handedly swing games with his scoring prowess. While John Tonje of Wisconsin may not have the same national recognition, his ability to carry the Badgers on a deep run cannot be underestimated. These four players represent the best of what the East Region has to offer, combining individual brilliance with the potential to lead their teams to glory.

Predicting the Winner of the East Region

When all is said and done, the East Region will likely crown Duke as its champion. The Blue Devils have the perfect combination of talent, experience, and coaching to make a deep run. With Cooper Flagg leading the charge, Duke’s balance, defense, and disciplined play make them the team to beat. While Alabama, Arizona, and BYU have the potential to challenge, Duke’s favorable draw and depth give them a significant edge. It would be a shock if the Blue Devils didn’t reach at least the Elite Eight, and with Flagg healthy, they are the clear favorites to win the region. The question now is whether they can take the next step and secure Jon Scheyer’s first Final Four appearance. With their loaded roster and mistake-free basketball, the answer seems to be a resounding yes. Duke is primed to dominate the East Region and make a strong case for a national championship.


This breakdown captures the excitement and intrigue of the East Region, highlighting the teams, players, and storylines that will define this year’s tournament. Whether it’s the brilliance of Cooper Flagg, the veteran leadership of Mark Sears, or the upset potential of Akron, there’s no shortage of drama and talent in the East Region.

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