Christina Applegate Opens Up About Her Ongoing Battle with Multiple Sclerosis
Christina Applegate, the beloved actress known for her roles in Married with Children and Dead to Me, has been courageously sharing her journey with multiple sclerosis (MS) on her podcast, MeSsy. In a recent episode, Applegate gave listeners a raw and unfiltered look at the physical and emotional challenges she has faced since her diagnosis in 2021. Speaking with cohost Jamie Lynn Sigler, Applegate revealed the sheer intensity of her struggles, stating that she has spent upwards of 30 hospital visits over the past three years due to symptoms like severe pain, vomiting, and diarrhea. "For three years, since I was diagnosed, I’ve been in the hospital upwards of 30 times from throwing up and diarrhea and pain," she shared, highlighting the grueling cycle of tests and treatments she has endured. Applegate also mentioned the overwhelming amount of radiation her body has been exposed to from CT scans and other medical procedures, underscoring the toll her condition has taken on her health.
Exploring the Link Between MS and Digestive Issues
During the episode, Applegate addressed a question from a fan who was struggling with similar symptoms, opening up about a potential connection between her MS and digestive issues. She shared that her recent experiences have led her to suspect a possible link between her MS symptoms and her digestive health, despite her neurologist dismissing the idea as unrelated. "If I have to poop, I puke," she bluntly confessed, describing the unbearable and often humiliating reality of her condition. Applegate advised listeners who experience similar symptoms to discuss motility issues with their doctors, as MS can slow down the functioning of vital organs. While she emphasized that she is not a medical professional and cannot provide formal advice, she urged her audience to consider the possibility of a correlation. "There’s got to be a correlation here, and I’m not a doctor. I’m not giving medical advice. I’m just saying, just think about that, OK? Because I’m in the middle of the same exact situation, and it f**ing sucks, and it’s scary," she said, speaking candidly about her frustrations and fears.
Finding Humor in the Struggles
Amid the serious and often heart-wrenching discussion, Applegate injected her signature humor into the conversation, offering a lighthearted yet practical piece of advice for anyone dealing with similar digestive challenges. "Always have a little trash can next to your toilet. Because you can do both without it being messy," she suggested, laughing as she admitted, "I had one yesterday." Her ability to find humor in such a difficult situation not only showcased her resilience but also helped normalize the conversation around topics that are often considered taboo. Applegate’s willingness to speak so openly about her struggles has resonated deeply with fans and listeners, many of whom have expressed gratitude for her honesty and vulnerability.
The Daily Struggles of Living with MS
Applegate also shared how her condition has impacted her daily life, revealing the small but significant challenges she faces every day. "I can’t open bottles now," she admitted, illustrating how MS has affected her strength and dexterity. These struggles are a far cry from the vibrant, energetic persona fans have come to know and love, making her candor all the more profound. Back in November 2024, Applegate had previously opened up about the intense pain she endures, describing it as "the sharp pains, the ache, the squeezing" that leave her "laying in bed screaming." Her honesty has shed light on the often invisible nature of chronic illness, reminding listeners that even someone as accomplished and seemingly strong as Applegate can struggle behind closed doors.
A Journey of Diagnosis and Advocacy
Applegate first began experiencing symptoms of MS in 2019, but it wasn’t until 2021 that she received an official diagnosis. The delay in diagnosis is a common experience for many people with MS, as the condition can be difficult to pinpoint due to its varied and often ambiguous symptoms. Since her diagnosis, Applegate has been on a mission to raise awareness about MS and support others who are navigating similar journeys. Through her podcast and public appearances, she has used her platform to share her story, offering hope and solidarity to those who may feel isolated by their own struggles. Her openness has not only humanized her as a celebrity but also empowered others to speak their truths and advocate for their health.
Christina Applegate: A Symbol of Resilience
Despite the many challenges she has faced, Applegate remains a symbol of resilience and courage. Her ability to laugh in the face of adversity, to advocate for herself and others, and to continue using her platform to make a difference is nothing short of inspiring. As she continues to navigate the complexities of life with MS, Applegate is proving that even in the darkest moments, there is strength to be found in vulnerability and hope to be shared through connection. Her journey serves as a reminder that no matter what challenges we face, we are never truly alone—and that even in the midst of struggle, there is always the possibility for growth, advocacy, and love.
